Constance Marie Lopez was born and raised in East Los Angeles, California, a third-generation Mexican-American.[1] that moved from apartment to apartment, and she was raised by her mother, who was an artist[2] and grandmother. While still in her teens, she began dancing and by age 19 she got a job tap-dancing in a musical in Japan by Ryuichi Sakamoto called "Cosmopolis". When she returned to Los Angeles, her career took a huge step when she was spotted in a club by a dance choreographer for pop icon David Bowie and started her career as a dancer on his Glass Spider Tour.

After arriving back from the tour, she was cast in a small role in the movie Salsa. After that, the film's choreographer introduced her to Steve Tisch, who gave her first acting job. She played Penny Rivera on CBS' television version of Dirty Dancing. She later won the role of Nikki Alvarez on the soap opera Santa Barbara. Constance Marie later appeared in Gregory Nava's film My Family. She played agent Toni Brigatti on Early Edition alongside Kyle Chandler. She was featured in the 1997 biographical film Selena opposite Jennifer Lopez in which she played Selena's mother, but under heavy make-up to make her look significantly older than the only four years younger Lopez. Another film credit was Tortilla Soup, in which she played a divorced mother. In 1997, she was cast in the short-lived NBC sitcom Union Square. She has guest-starred on many television shows such as FOX's Ally McBeal. She played Angie Lopez on the ABC sitcom George Lopez until its cancellation in 2007. From 2002 until 2004 she played Nina Gonzales on the critically-acclaimed PBS miniseries American Family. She made a guest appearance as herself on an episode of Statler and Waldorf: From the Balcony. She has volunteered as an actress with the Young Storytellers Foundation. More recently, she did an episode of "The Secret Life of the American Teenager" as Marc Molina's wife, Virginia Molina.
Marie is engaged to yoga coach Kent Katich. They have a daughter, Luna Marie, born on February 5, 2009. in Santa Monica, California.

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